RNA Interference Appears Effective against Several Viruses

RNA interference directs innate immunity against viruses in adult Drosophila.

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double...

RNA interference & inhibition of viruses.

147 RNA interference (RNAi) is emerging as a new strategy to selectively shut off the post-transcriptional expression of mRNA. This evolutionarily maintained mechanism has been detected from yeast to mammalian cells. Rapid, inexpensive and selective silencing of a gene product in complex biological systems obviously has opened new avenues in fields of virology, cancer research, genetic disorder...

RNA interference against retroviruses.

Bang and Ellerman, and later Peyton Rous, reported the first identification of transmissible cancer-causing agents, which later turned out to be avian retroviruses. Today avian retroviruses are important models for study of retrovirus replication and pathogenesis, and also important pathogens of domestic fowl. Here we describe the use of RNA interference (RNAi) in live chick embryos to block re...

1 Silencing Viruses by Rna Interference

Post-transcriptional gene silencing (PTGS) makes possible new approaches for studying the various steps of the viral cycle. Plus-strand RNA viruses appear to be attractive targets for small interfering RNAs (siRNAs), as their genome functions as both mRNA and replication template. PTGS creates an alternative to classic reverse genetics for viruses with either negative-strand or double-stranded ...

How RNA Interference Combat Viruses in Plants